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Ro3280 NEW

Price	$55	$146	$198
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: Ro3280	CAS No.: 1062243-51-9
Purity: 98%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	Ro3280
Description	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
In vitro	In nude mice implanted with HT-29 human colon tumors, RO3280 (40 mg/kg) was effective in inhibiting tumor cell proliferation.
In vivo	RO3280 exhibits antitumor activity across a variety of tumor cell lines, effectively inhibiting cancer cell proliferation. Specifically, it demonstrates potency against lung cancer cell line H82 (IC50=5 nM), colorectal cancer cell HT-29 (IC50=10 nM), breast cancer cell MDA-MB-468 (IC50=19 nM), prostate cancer cell PC3 (IC50=12 nM), and skin cancer cell A375 (IC50=70 nM).
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 27.2 mg/mL (50 mM) Ethanol : 27.2 mg/mL (50 mM)
Keywords	Ro3280 \| Inhibitor \| Polo-like Kinase (PLK) \| RO-3280 \| inhibit \| Ro-3280
Inhibitors Related	Onvansertib \| Plogosertib \| T521 \| (E/Z)-Rigosertib sodium \| SBE13 Hydrochloride \| Pyridoxine \| Rigosertib sodium \| 3MB-PP1 \| Volasertib \| Poloxin-2 \| BI 2536 \| GSK461364
Related Compound Libraries	Highly Selective Inhibitor Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Hematonosis Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Fluorochemical Library \| Covalent Inhibitor Library \| Cell Cycle Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.