Rituximab NEW
| Price | $229 | $557 | $812 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Rituximab | CAS No.: 174722-31-7 |
| Purity: 98.20% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Rituximab |
| 描述 | Rituximab is an anti-CD20 chimeric monoclonal antibody used to study certain autoimmune diseases and cancers. |
| 細(xì)胞實(shí)驗(yàn) | Objective: Complement-mediated cell lysis. Concentrations: 0, 0.02, 0.2, 2, 20 μg/mL. Incubation Time: 2 h. Method: Lymphoma B cells were purified from lymph node biopsies of patients with B-cell lymphoma. Rituximab was added to tumor cells (1×106 /mL) in complete medium supplemented by human serum, inactivated or not by incubation at 56°C for 30 minutes. After 2 hours at 37°C, cell lysis was determined by PI staining of cells and analysis by flow cytometry. |
| 體外活性 | METHODS: B cells were treated with 0, 2.5, 5 and 10 μg/mL Rituximab to observe the effect of Rituximab on B cell proliferation. RESULTS There was an optimal inhibition of B cell proliferation at a concentration of 5 μg/mL. [1] |
| 體內(nèi)活性 | METHODS: 100 mg of Rituximab was administered over 4 h. Rituximab was then infused in a regimen of 3 weekly infusions for 4 weeks, and caspase-3 and PARP expression and protein hydrolysis processes were examined in patients. RESULTS Rituximab induced cleavage of caspase-3, followed by the appearance of a 17-kd cleavage product corresponding to the large subunit of the catalytically active protease, and cleavage of PARP, a known substrate of cysteine asparaginase, was also detected. [2] |
| 存儲(chǔ)條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 關(guān)鍵字 | Rituximab |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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