Rhosin hydrochloride NEW
| Price | $162 | $229 | $347 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Rhosin hydrochloride | CAS No.: 1281870-42-5 |
| Purity: 98.92% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Rhosin hydrochloride |
| 描述 | Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases and inhibits the RhoA-GEF interaction. Rhosin hydrochloride can significantly induce cell apoptosis without affecting cell cycle progression. [1] |
| 體外活性 | METHODS: To investigate the cytotoxic effects of Rhosin hydrochloride on B16BL6 and 4T1 cells, cell viability was assessed by treating cells with 1-100 μM Rhosin hydrochloride. RESULTS Rhosin hydrochloride at a concentration of 100 μM induced cell death in B16BL6 and 4T1 cells. [1] |
| 體內(nèi)活性 | METHODS: B16BL6 cells and 4T1 cells were injected into the tail vein of syngeneic C57BL/6J mice and Balb/c mice. Mice were treated with 10 or 30 mg/kg of Rhosin hydrochloride daily from day 1 to day 14. RESULTS The number of lung metastatic nodules in B16BL6 and 4T1 cells was reduced in a dose-dependent manner after administration of Rhosin hydrochloride, and Rhosin hydrochloride inhibited the metastasis of 4T1-luc tumor cells to the lung region, which could be confirmed by the reduction of photon flux. [1] |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (253.25 mM), Sonication is recommended. |
| 關(guān)鍵字 | plasticity | D1-MSN | MCF7 | Apoptosis | hyperexcitability | Rhosin hydrochloride | Ras | stress | Rhosin | selective | inhibit | cells | Inhibitor | resiliency | Rhosin Hydrochloride |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| 相關(guān)庫 | 細(xì)胞凋亡化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 抑制劑庫 | PPI抑制劑庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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