Product Details
| Product Name:
Rezivertinib |
CAS No.:
1835667-12-3 |
| Purity:
99.43% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Rezivertinib |
| Description | Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders. |
| In vitro | Rezivertinib selectively inhibits cellular proliferation of EGFR mutations in cell lines: PC9 (GI50=13.3 nM), HCC827 (GI50=6.8 nM), NCI-H1975 (GI50=22 nM) and A431 (GI50>1000 nM). [1] |
| In vivo | Rezivertinib administered orally for 14 days at 6.25-25 mg/kg/day demonstrated significant tumor regression. In addition, Rezivertinib administered orally at 50 mg/kg/day also showed anti-tumor effects, significantly improving the mean overall survival of the animals, which was prolonged from 13 to 28 days, a 115% improvement. [2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL, (205.52 mM.), Sonication is recommended.
|
| Keywords | Rezivertinib |
| Inhibitors Related | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Afatinib Dimaleate | Erlotinib hydrochloride | Erlotinib | Neratinib | Osimertinib mesylate | Chalcone | Genistein | Khellin | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States