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Postion:Product Catalog >Analytical Chemistry>Standard>Food and cosmetics standards>Retrorsine
Retrorsine
  • Retrorsine

Retrorsine NEW

Price $35
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Retrorsine CAS No.: 480-54-6
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameRetrorsine
DescriptionRetrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
In vitroRetrorsine inhibited the OCT1-mediated 1-methyl-4-phenylpyridinium (MPP(+)) uptake in MDCK-hOCT1 cells with the IC50 of 2.25±0.30μM[1]. Retrorsine (60 μM, 120 μM , 240 μM; 24 h) significantly reduced HSEC-CYP3A4 cell viability and GSH levels and increases the formation of pyrrole-protein adducts[2].
In vivoIn male Wistar rats, Retrorsine (30 mg/kg; i.p.; twice) impaired liver regeneration in the PBL model not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle[3].
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 95 mg/mL (270.35 mM), Sonication is recommended.
Keywordspyrrolizidine | inhibit | hepatotoxic | hepatocellular | Inhibitor | Retrorsine | injury | alkaloid
Inhibitors RelatedTebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Naringin | Naringenin | Tauroursodeoxycholate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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