Reserpine NEW
| Price | $36 | $52 | $125 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Reserpine | CAS No.: 50-55-5 |
| Purity: 99.6% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Reserpine |
| Description | Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. |
| In vitro | Compared to the control group, alternate-day subcutaneous injections of reserpine solution (1 mg/kg s.c.) for three days significantly increased the duration of vacuous chewing, tongue protrusion, and facial twitching in rats. Reserpine reduced glutamate uptake in the cortical region of rats and caused a significant depletion of vasopressin/oxytocin - neurophysin-like immunoreactivity (LI) and CRH-L1 in the rat's median eminence. Additionally, reserpine notably restored performance in the delayed response task in monkeys. At a dose of 5 mg/kg, reserpine significantly increased pointless jaw movements in monkeys and reduced grooming behavior across all age groups in rats. A subcutaneous injection of 5 mg/kg reserpine in intact rats decreased extracellular dopamine levels to 4% of baseline values. The impact of reserpine on performance in a visual discrimination task, a reference memory task not reliant on the prefrontal cortex, was minimal. |
| In vivo | Reserpine was demonstrated to inhibit efflux pumps in 11, 21, and 48 out of the 102 unrelated clinical isolates tested, resulting in a fourfold decrease in the IC50 values and MICs of sparfloxacin, moxifloxacin, and ciprofloxacin, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (82.14 mM) |
| Keywords | Monoamine Transporter | Inhibitor | Reserpine | inhibit | Autophagy |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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