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Postion:Product Catalog >API>Hormones and the Endocrine System>Pancreatic hormone and blood sugar regulation>Repaglinide
Repaglinide
  • Repaglinide

Repaglinide NEW

Price $54 $79 $102
Package 50mg 100mg 200mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Repaglinide CAS No.: 135062-02-1
Purity: 99.66% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameRepaglinide
DescriptionRepaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury.
In vitroRepaglinide binds to NCS proteins in a calcium-dependent manner, but does not bind to CAM or S100 proteins.Repaglinide tightly binds to CCaMK and PpCaMK in a calcium-dependent manner, antagonizing the regulatory function of the structural domains, with IC 50 values of 55 mM and 4 mM for the CCaMK and PpCaMK domains.Repaglinide binds to CCaMK and PpCaMK domains with low affinity (K(D) = 59 nM) to bind SUR1 alone, but binds SUR1 with high affinity to co-express with Kir6.2, increasing it approximately 150-fold.Repaglinide antagonizes the inhibitory effect of restoring protein in the retinal kinase assay, with an IC50 value of 400 mM.Repaglinide also antagonizes the inhibitory effect of restoring protein in the retinal kinase assay, with an IC50 value of 400 mM.
In vivoRepaglinide binds to NCS proteins in a calcium-dependent manner, but does not bind to CAM or S100 proteins.Repaglinide tightly binds to CCaMK and PpCaMK in a calcium-dependent manner, antagonizing the regulatory function of the structural domains, with IC 50 values of 55 mM and 4 mM for the CCaMK and PpCaMK domains.Repaglinide binds to CCaMK and PpCaMK domains with low affinity (K(D) = 59 nM) to bind SUR1 alone, but binds SUR1 with high affinity to co-express with Kir6.2, increasing it approximately 150-fold.Repaglinide antagonizes the inhibitory effect of restoring protein in the retinal kinase assay, with an IC50 value of 400 mM.Repaglinide also antagonizes the inhibitory effect of restoring protein in the retinal kinase assay, with an IC50 value of 400 mM.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 84 mg/mL (185.6 mM)
DMSO : 55 mg/mL (121.52 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywordsmellitus. | Repaglinide | inhibit | Inhibitor | benzoic | type-2 | insulin | secretagogue | CMBA | diabetes | acid | carbamoylmethyl
Inhibitors RelatedMinoxidil sulfate | PHYTOL | Daidzein | Fenofibrate | Halothane | 5-Aminosalicylic Acid | Naringenin | Cloperastine hydrochloride | Fisetin | 2,3-Butanediol | Icariin | Indapamide
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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