R 59-022 hydrochloride NEW
| Price | $38 | $89 | $147 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: R 59-022 hydrochloride | CAS No.: 93076-98-3 |
| Purity: 97.7% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | R 59-022 hydrochloride |
| Description | R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 μM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils. |
| In vitro | R 59-022 (10 μM; 1 min) Hydrochloride enhances platelet aggregation.[1] R 59-022 (30 μM; 0-60 min) Hydrochloride increases the release of norepinephrine in chromaffin cells.[2] R 59-022 (40 μM; 30 min) Hydrochloride activates PKC in HeLa and U87 cells.[3] R 59-022 (0-10 μM; 4 h) Hydrochloride blocks the entry of EBOV GP into Vero cells.[4] |
| In vivo | R 59-022 (2 mg/kg; i.p.; 12 days) significantly increased the median survival of SCID mice implanted with U87 GBM cells.[6] |
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (110.88 mM) |
| Keywords | R 59-022 Hydrochloride | Diacylglycerol kinase inhibitor I Hydrochloride | DKGI-I Hydrochloride |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | α-Vitamin E | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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