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Postion:Product Catalog >QL-X-138 HCl
QL-X-138 HCl
  • QL-X-138 HCl

QL-X-138 HCl NEW

Price $195 $483 $692
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: QL-X-138 HCl Purity: 98.89%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameQL-X-138 HCl
DescriptionQL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia.
In vitroIn Ramos, OCI-AML3, U2932, TMD8, and U937 cells, QL-X-138 HCl(3-10000 nM; 4 hours) significantly inhibited the auto-phosphorylation of BTK Y223 (EC50=11 nM).QL-X-138 HCl strongly blocked the phosphorylation of the BTK downstream target PLCγ2 Y1217 (EC50=57 nM) and suppressed the phosphorylation of the MNK downstream target eIF4E S209 at a concentration of 1 μM[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Inhibitors Relatedevobrutinib | (±)-Zanubrutinib | CP-547632 | BMS-986142 | Ibrutinib | IBT6A | Orelabrutinib | Atuzabrutinib | MK2-IN-3 hydrate | CGI-1746
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

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Hebei Dangtong Import and export Co LTD
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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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