Product Details
| Product Name:
QF0301B |
CAS No.:
149247-12-1 |
| Purity:
99.16% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | QF0301B |
| Description | QF0301B is a potent α1-adrenergic receptor antagonist with inhibitory effects on α2-adrenergic receptors, 5-HT2A and histamine H1 receptors. |
| In vitro | QF0301B exhibits marked α1-adrenoceptor blocking activity in isolated rubbed rat aorta rings, with a pA2 value of 9.00±0.12. In electrically stimulated rat vas deferens, QF0301B reverses and competitively antagonizes the inhibitory action produced by clonidine. Additionally, it inhibits the force and rate of contraction in rat isolated atria (pA2=5.91±0.43), competitively antagonizes the contractile effect of 5-HT in rat aorta (pA2=6.75±0.06) and in rat stomach fundus (pA2=7.13±0.48), as well as the contractions induced by histamine in isolated guinea pig longitudinal ileal muscle (pA2=7.40±0.40). QF0301B shows noncompetitive low action in 5-HT3, muscarinic, and nicotinic receptors, as well as Ca2+ antagonist[1]. |
| In vivo | QF0301B (0.1-0.2 mg/kg iv) induces a significant and prolonged decrease in mean arterial blood pressure accompanied by bradycardia. It does not significantly alter the cardiovascular effects of either 5-hydroxytryptamine (serotonin, 5-HT, 75 mg/kg iv) or the selective α2-adrenoceptor agonist B-HT 920 (0.2 mg/kg iv). However, QF0301B markedly inhibits the hypertensive effect of noradrenaline (5 mg/kg iv), a nonselective α-adrenergic receptor agonist[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | QF0301B | QF-0301B |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Octopamine hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Isoprenaline hydrochloride | Amitriptyline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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