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Postion:Product Catalog >Food Additives>Nutrition supplements>Vitamins>Pyridoxine hydrochloride
Pyridoxine hydrochloride
  • Pyridoxine hydrochloride
  • Pyridoxine hydrochloride

Pyridoxine hydrochloride NEW

Price $6 $0.2
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: Pyridoxine hydrochloride CAS No.: 58-56-0
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information


Names

Namepyridoxine hydrochloride
SynonymMore Synonyms

 Pyridoxine hydrochloride Biological Activity

DescriptionPyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Neurological Disease
Natural Products >> Others
Target

Nrf2[1]

In VitroPyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References

[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

 Chemical & Physical Properties

Boiling Point491.9oC at 760 mmHg
Melting Point214-215 °C(lit.)
Molecular FormulaC8H12ClNO3
Molecular Weight205.639
Flash Point251.3oC
Exact Mass205.050568
PSA73.58000
LogP0.88220
Storage condition2-8°C
StabilityStable. Protect from air and light.
Water Solubility0.1 g/mL (20 oC)

 MSDS

Pyridoxine hydrochloride MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • UV1350000

  • CHEMICAL NAME :

  • Pyridoxol, hydrochloride

  • CAS REGISTRY NUMBER :

  • 58-56-0

  • LAST UPDATED :

  • 199712

  • DATA ITEMS CITED :

  • 24

  • MOLECULAR FORMULA :

  • C8-H11-N-O3.Cl-H

  • MOLECULAR WEIGHT :

  • 205.66

  • WISWESSER LINE NOTATION :

  • T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 4 gm/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 3 gm/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 530 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 5500 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 2450 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 660 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • >500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 1 gm/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 560 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intramuscular

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 500 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 464 mg/kg

  • TOXIC EFFECTS :

  • Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Bird - pigeon

  • DOSE/DURATION :

  • 145 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 21400 mg/kg/15W-I

  • TOXIC EFFECTS :

  • Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 2 mg/kg

  • SEX/DURATION :

  • female 38 week(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - postpartum

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intramuscular

  • DOSE :

  • 2 mg/kg

  • SEX/DURATION :

  • female 38 week(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - postpartum

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 8040 ug/kg

  • SEX/DURATION :

  • female 14 week(s) pre-mating - 12 day(s) post-birth

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 4 gm/kg

  • SEX/DURATION :

  • female 6-15 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 15 gm/kg

  • SEX/DURATION :

  • male 2 week(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Paternal Effects - testes, epididymis, sperm duct

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 7500 mg/kg

  • SEX/DURATION :

  • male 6 week(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 15 gm/kg

  • SEX/DURATION :

  • male 6 week(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

  • TYPE OF TEST :

  • Sister chromatid exchange

  • TEST SYSTEM :

  • Human Lymphocyte

  • DOSE/DURATION :

  • 2 mg/L

  • REFERENCE :

  • MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)

 Safety Information

SymbolArticle illustration Article illustration Article illustration
GHS02, GHS06, GHS08
Signal WordDanger
Hazard StatementsH225-H301 + H311 + H331-H370
Precautionary StatementsP210-P260-P280-P301 + P310-P311
Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi:Irritant
Risk PhrasesR36/37/38
Safety PhrasesS26-S37/39
RIDADRNONH for all modes of transport
WGK Germany2
RTECSUV1350000
HS Code2936250000

 Synthetic Route

Previous 1/8 Next
Article illustration

TRI-ACETYL PYRI...

10030-93-0

~96%

Article illustration

Pyridoxine hydr...

58-56-0

Literature: Geiger; Lalonde; Stoller; Schleich Helvetica Chimica Acta, 1984 , vol. 67, # 5 p. 1274 - 1282
Article illustration

Pyridoxamine di...

524-36-7

~25%

Article illustration

Pyridoxine hydr...

58-56-0

Literature: DSM IP ASSETS B.V. Patent: WO2006/66806 A1, 2006 ; Location in patent: Page/Page column 16 ;
Article illustration

N/A

90330-16-8

~76%

Article illustration

Pyridoxine hydr...

58-56-0

Literature: Shimada, Sadakatsu; Oki, Masaharu Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 38 - 43

 Precursor & DownStream

Precursor  9

Previous 1/3 Next

  • Article illustration CAS#:10030-93-0
    TRI-ACETYL PYRI...

  • Article illustration CAS#:524-36-7
    Pyridoxamine di...

  • Article illustration CAS#:4469-34-5
    1,3-Dioxepin,4,...

  • Article illustration CAS#:24201-52-3
    5-butoxy-4-meth...

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:529-96-4
    pyridoxamine ph...

  • Article illustration CAS#:94-75-7
    2,4-Dichlorophe...

  • Article illustration CAS#:447-05-2
    pyridoxine 5'-p...

  • Article illustration CAS#:948-00-5
    3,3,8-trimethyl...

 Customs

HS Code2936250000
SummaryHS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621








Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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