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Postion:Product Catalog >Pyrazolo[1,5-a]pyrimidine 4h
Pyrazolo[1,5-a]pyrimidine 4h
  • Pyrazolo[1,5-a]pyrimidine 4h

Pyrazolo[1,5-a]pyrimidine 4h NEW

Price $44 $61 $109
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Pyrazolo[1,5-a]pyrimidine 4h CAS No.: 597544-21-3
Purity: 99.01% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePyrazolo[1,5-a]pyrimidine 4h
DescriptionPyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chorea.
In vivoOnly Parthenolide, the HDAC inhibitor with anti-inflammatory features, displayed a potent anti-apoptotic effect in Phb1 KO hepatocytes. Indeed, TSA and Parthenolide-treated hepatocytes showed increased levels of FXR, and reduced levels of CYP7A1, HDAC4, TNFα, TRAIL and Bax suggesting a less toxic effect of bile acids as a results of specific HDAC inhibition, resulting in the attenuation of the Phb1 KO hepatocytes apoptotic response. Importantly, Parthenolide exerts a protective effect from the liver injury after BDL in Phb1 KO mice. Indeed, Parthenolide treatment results in a reduction of the mortality rate of this mice after BDL associated with a lower apoptotic response as revealed by a reduction of necrotic areas, Tunel-staining, as well as decreased ALT (8431±957 vs.4225±210 U/L) and AST (4805±300 vs.2242±438 U/L) activities compared to control Phb1 KO mice[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 25 mg/mL (62.27 mM), Sonication is recommended.
KeywordsPyrazolo[1,5a]pyrimidine 4h | Pyrazolo[1,5-a]pyrimidine 4h | Pyrazolo[1,5 a]pyrimidine 4h
Related Compound LibrariesBioactive Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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