Protoporphyrin IX NEW
| Price | $42 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Protoporphyrin IX | CAS No.: 553-12-8 |
| Purity: 99.75% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Protoporphyrin IX |
| 描述 | Protoporphyrin IX (PPIX) is a tetrapyrrole that is a metabolic precursor of heme, cytochrome c, and chlorophyll. Protoporphyrin IX has been shown to improve liver function, promote cellular tissue respiration, improve protein and glucose metabolism, and resist complement binding. |
| 體外活性 | METHODS: Gastric cancer cells SGC-7901 and MGC-80 were treated with Stigmasterol (2.5-30 μM) for 24-72 h. Cell viability was measured by CCK8 assay. RESULTS: Stigmasterol significantly inhibited the viability of SGC-7901 and MGC-803 cells in a time- and dose-dependent manner. [1] METHODS: Ovarian cancer cells ES2 and OV90 were treated with Stigmasterol (5-20 μg/mL) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Stigmasterol stimulated caspase 3 and caspase 9 cleavage in a dose-dependent manner in each cell type. cytochrome c, BAK and BAX were activated by Stigmasterol in both cell types. alpha-tubulin levels were unchanged after Stigmasterol treatment. The level of alpha-tubulin did not change after Stigmasterol treatment. [2] |
| 體內(nèi)活性 | METHODS: To investigate the role in allergic skin reactions, Stigmasterol (10-100 mg/kg) was administered intraperitoneally to ICR mice with induced irritant dermatitis. RESULTS: Stigmasterol significantly inhibited IgE-mediated active cutaneous allergic reactions (ACA), reducing the area of reaction and the concentration of exuded Evans blue dye. Stigmasterol significantly inhibited C48/80-induced scratching behavior compared to control. Skin histopathology at the injection site confirmed that Stigmasterol reduced mast cell transport and degranulation associated with C48/80-induced itching. [3] |
| 存儲(chǔ)條件 | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5.63 mg/mL (10 mM) |
| 關(guān)鍵字 | inhibit | Endogenous Metabolite | Protoporphyrin IX | Inhibitor |
| 相關(guān)產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 大環(huán)化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥單體化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 人內(nèi)源代謝化合物庫(kù) | 已知活性化合物庫(kù) | 藥食同源庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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