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Postion:Product Catalog >Biochemical Engineering>Inhibitors>DNA damage>DNA / RNA Synthesis inhibitors>Procarbazine hydrochloride
Procarbazine hydrochloride
  • Procarbazine hydrochloride
  • Procarbazine hydrochloride
  • Procarbazine hydrochloride
  • Procarbazine hydrochloride
  • Procarbazine hydrochloride

Procarbazine hydrochloride NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 50000KG/month
Update Time: 2023-09-07

Product Details

Product Name: Procarbazine hydrochloride CAS No.: 366-70-1
EC-No.: 206-678-6 Min. Order: 1KG
Purity: 99% Supply Ability: 50000KG/month
Release date: 2023/09/07

CAS:366-70-1
MF:C12H20ClN3O
MW:257.76
EINECS:206-678-6
Product Categories:API;Matulane;Intermediates & Fine Chemicals;Pharmaceuticals;366-70-1
Mol File:366-70-1.mol
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Procarbazine hydrochloride Chemical Properties
Melting point 223°C
density 8.3 g/cm3
storage temp. Inert atmosphere,2-8°C
solubility DMSO: ≥18mg/mL
form powder
color white to tan
Water Solubility >=10 g/100 mL at 21.5 oC
Merck 14,7758
BCS Class3/1
CAS DataBase Reference366-70-1(CAS DataBase Reference)
IARC2A (Vol. 26, Sup 7) 1987
EPA Substance Registry SystemProcarbazine hydrochloride (366-70-1)
Procarbazine hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline Solid
Chemical PropertiesProcarbazine is a white to pale yellow crystal- line powder with a slight odor.
UsesProcarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
UsesAntineoplastic.
UsesAntineoplastic;DNA replication inhibitor
DefinitionChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.
Brand nameMatulane (Sigma-Tau).
General DescriptionWhite to pale yellow crystalline powder with a slight odor. Acid to litmus.
General DescriptionProcarbazine is available in 50-mg tablets for oral administrationin the treatment of Hodgkin’s (part of MOPP) andnon-Hodgkin’s disease, brain cancer, and mycosis fungoides.The major mechanisms of resistance appear to beenhanced activity of DNA-repair enzymes including enhancedO-6-alkylguanine DNA transferase (AGAT),which removes the methyl group from the O-6 of guanine.The agent is rapidly and completely absorbed after oral administrationand extensively metabolized in the liver togive azo-procarbazine followed by further oxidation tomethyldiazine and the aldehyde. The parent drug andmetabolites cross the blood-brain barrier. Elimination occursin the urine mostly as metabolites with an eliminationhalf-life of 1 hour. Myelosuppression is dose limiting, generallypresenting as thrombocytopenia that may be followedby leucopenia. Glucose-6-phosphate dehydrogenasedeficient patients may develop hemolytic anemia duringprocarbazine therapy. Other adverse effects include nausea,vomiting, hypersensitivity, flulike symptoms, amenorrhea,and azoospermia. Central nervous symptom effectsmay be seen, including lethargy, confusion, neuropathies,and seizure.
Air & Water ReactionsIn the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reactivity ProfileProcarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
Fire HazardFlash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.
Potential ExposureProcarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.
Veterinary Drugs and TreatmentsIn veterinary medicine, procarbazine is used as part of MOPP protocols (mechlorethamine, vincristine, procarbazine, prednisone) to treat lymphomas in dogs and cats. It may be of benefit in treating granulomatous meningoencephalitis (GME) in dogs.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Quantity(Kilograms)1 - 10000>10000
Est. Time(days)5To be negotiated

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Article illustrationCompany information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

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