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Postion:Product Catalog >Pregnenolone Carbonitrile
Pregnenolone Carbonitrile
  • Pregnenolone Carbonitrile

Pregnenolone Carbonitrile NEW

Price $49
Package 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Pregnenolone Carbonitrile CAS No.: 1434-54-4
Purity: 99.64% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePregnenolone Carbonitrile
DescriptionPregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
In vitroPregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4].
In vivoIn WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 30 mg/mL (87.85 mM), Sonication and heating to 60℃ are recommended.
KeywordsCYPs | Cytochrome P450 | P4503A | orally | 5-Pregnen-3b-ol-20-one-16a-carbonitrile | 5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile | Inhibitor | Pregnenolone Carbonitrile | PXR | cytochrome | inhibit | Pregnenolone 16α-carbonitrile | Pregnenolone 16alpha-carbonitrile | Pregnenolone 16a-carbonitrile
Inhibitors RelatedTebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride
Related Compound LibrariesNuclear Receptor Compound Library | Bioactive Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Anti-Cancer Compound Library | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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