Pravastatin sodium NEW
| Price | $40 | $55 | $66 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Pravastatin sodium | CAS No.: 81131-70-6 |
| Purity: 99.08% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Pravastatin sodium |
| Description | Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM. |
| In vitro | Pravastatin (30 mg/kg/day) reduced malnutrition-induced lesions by 34%. In female Wistar rats exposed to radiation, which presented with decreased CCN2 levels, Pravastatin (30 mg/kg/day) could restore muscle structure. A single dose of 40 mg of Pravastatin lowered cholesterol synthesis by 62% in monocytes from healthy individuals and by 47% in patients with hypercholesterolemia. Moreover, treatment with Pravastatin (40 mg/day for 8 weeks) in hypercholesterolemic patients increased LDL degradation by 57% while inhibiting cholesterol synthesis by 55%. |
| In vivo | In murine peritoneal macrophages (MPM), the J-774 A.1 macrophage-like cell line, and human monocyte-derived macrophages (HMDM), Pravastatin exhibits a dose-dependent inhibition of cholesterol synthesis. Upon LDL addition, concentrations of Pravastatin below 0.19 μg/mL enhance the esterification of cellular cholesterol, whereas levels below 100 μg/mL suppress esterification. At less than 0.5 mM, Pravastatin attenuates the Rho/ROCK pathway activity in human ileal and colonic transplants, reducing CCN2 mRNA levels. Pravastatin at concentrations less than 1 mM also induces the inhibition of CCN2 in primary human smooth muscle cells. In all cases, Pravastatin at less than 0.5 mM reduces the mRNA levels of type I collagen and fibronectin. Pravastatin facilitates vasodilation in aortic rings, achieving 62.8% endothelium-dependent relaxation at 10 μM after 8 minutes. Pravastatin-Na at 10 μM inhibits sterol synthesis with 50% greater efficacy than in peripheral blood mononuclear cells. In bovine aortic endothelial cells, Pravastatin at less than 10 μM stimulates NOS activity and NO release within 10 minutes, with L-arginine further enhancing NO production in response to Pravastatin. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 44.7 mg/mL (100 mM) DMSO : 45 mg/mL (100.78 mM), Sonication is recommended. |
| Keywords | Pravastatin | Autophagy | CS514 | HMG-CoA Reductase (HMGCR) | Ferroptosis | inhibit | Pravastatin sodium | Inhibitor | CS 514 | CS-514 |
| Related Compound Libraries | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Microbial Natural Product Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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