Pranlukast NEW
Price | $50 | $72 | $90 |
Package | 25mg | 50mg | 100mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: Pranlukast | CAS No.: 103177-37-3 |
Purity: 99.85% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | Pranlukast |
Description | Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. |
In vitro | Pranlukast significantly reduces the volume of injury in the cortical and hippocampal CA1 regions of the ischemic hemisphere in mice and increases neuronal density. Additionally, Pranlukast markedly thins the scar wall in the ischemic hemisphere of mice. |
In vivo | In sensitized guinea pig tracheas, 5 mM of either Pranlukast or Zafirlukast significantly inhibited ovalbumin-induced secretion by 70% and 65%, respectively. These compounds also markedly inhibited 35SO4 release triggered by 10 mM LTD4 in a concentration-dependent manner, with Pranlukast showing a peak inhibition of 83% and Zafirlukast 78% at 10 mM, having IC50 values of 0.3 mM and 0.6 mM, respectively. Pranlukast suppressed the activation of NF-κB in 1.3% DMSO-differentiated U-937 and Jurkat cells, with inhibition rates of 40% and 30%; it also demonstrated a dose-dependent inhibition of NF-κB activation in combination with MK-571. Pranlukast and MK-571 diminished LPS-induced IL-6 production in PBMCs by approximately 65% and 15%. Additionally, Pranlukast inhibited the activation of NF-κB induced by phorbol 12-myristate 13-acetate and significantly reduced LPS-induced MUC2 mRNA expression in NCI-H292 cells, as determined by reverse transcription-polymerase chain reaction. Pranlukast also suppressed the expression of the MUC2 gene in LPS-stimulated HM3-MUC2 cells. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 45 mg/mL (93.46 mM) |
Keywords | Inhibitor | inhibit | Leukotriene Receptor | ONO 1078 | ONO1078 | Pranlukast |
Inhibitors Related | Acetylcysteine | Diethylmaleate | Glucosamine | Lidocaine hydrochloride | L-Arginine | Apremilast | Indole-3-carbinol | Diallyl disulfide |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Human Metabolite Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$10.00/1KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-12-03 | |
$50.00/25mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$10.00/1kg |
VIP1Y
|
Hebei Ganmiao New material Technology Co., LTD
|
2024-06-06 | |
$5.00/25kg |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-28 | ||
$0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-08-15 | |
$0.00/25kg |
Zhejiang Hengkang Pharmaceutical Co., Ltd.
|
2022-09-02 | ||
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
$1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-06-01 | |
$0.00/20KG |
Qiuxian Baitai New Material Co., LTD
|
2021-03-17 | ||
$1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2018-08-20 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY