Polymyxin B NEW
| Price | $34 | $46 |
| Package | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Polymyxin B | CAS No.: 1404-26-8 |
| Purity: 91% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Polymyxin B |
| 描述 | Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia. |
| 體外活性 | 10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs). [3] |
| 體內(nèi)活性 | Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose. [2] |
| 存儲條件 | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 30 mg/mL, Adjust pH to 2 and sonication is recommended. |
| 相關產(chǎn)品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Crystal Violet |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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