Product Details
| Product Name:
Pivagabine |
CAS No.:
69542-93-4 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Pivagabine |
| 描述 | Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain. |
| 動物實(shí)驗(yàn) | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2]. |
| 體內(nèi)活性 | Pivagabine (CXB 722) (200 mg/kg; i.p.; administered twice daily for 4 days and 1 hour before euthanasia on the 5th day) prevents foot-shock stress-induced changes in CRF concentration in both brain regions[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (240.33 mM), Sonication is recommended.
|
| 關(guān)鍵字 | blood-brain | γ-Aminobutyric acid Receptor | Pivagabine | psychoactive | derivative | Inhibitor | inhibit | foot | factor | barrier | CXB722 | shock | Gamma-aminobutyric acid Receptor | CXB 722 | GABA Receptor | neuromodulatory | corticotropin-releasing |
| 相關(guān)產(chǎn)品 | Valproic acid sodium salt | DL-Menthol | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Piperazine citrate | Riluzole | Gabapentin | (-)-α-Pinene |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 神經(jīng)退行性疾病化合物庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$30.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States