Pimobendan NEW
| Price | $32 | $55 | $89 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Pimobendan | CAS No.: 74150-27-9 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Pimobendan |
| Description | Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM). |
| In vitro | Compared to the control group, Pimobendan (1 mg/kg) significantly reduced the permeability of cardiomyocytes and also decreased the levels of TNF-α and IL-1β within the chamber without affecting myocardial nerves, heart weight, and body weight. In a mouse model of EMC virus-induced myocarditis, Pimobendan contributed to an extension of lifespan. The final survival rate was significantly increased from 33.6% (control group) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Additionally, Pimobendan inhibited the expression of inducible nitric oxide synthase genes in the heart, thereby reducing the content of nitric oxide within the heart. |
| In vivo | When administered to human atrial cells, Pimobendan (100 μM) increased the L-type calcium current by 250.4% (EC50: 1.13 μM). Its effect on rabbit atrial cells was significantly lower, resulting in a 67.4% increase in ICa(L). Pimobendan exhibits selective inhibitory action on isolated PDE III in guinea pig myocardium (IC50: 0.32 μM), with much higher IC50s for PDE I and PDE II (>30 μM). It also inhibits cAMP-PDE III activity (IC50: 2.4 μM) and induces a positive inotropic effect on isolated guinea pig papillary muscles (EC50: 6.0 μM), partially due to its selective inhibition of myocardial PDE III. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (164.49 mM) Ethanol : 5 mg/mL (14.95 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | inhibit | Pimobendan | UD-CG-115 | UD-CG 115 | Phosphodiesterase (PDE) | Inhibitor |
| Inhibitors Related | Theophylline monohydrate | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Doxofylline |
| Related Compound Libraries | Highly Selective Inhibitor Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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