Product Details
| Product Name:
PHTPP |
CAS No.:
805239-56-9 |
| Purity:
99.72% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | PHTPP |
| Description | PHTPP is a selective ERβ antagonist. |
| Cell Research | Cells are plated at a density of 3 to 4×10^5 in 1 mL of medium per well in a 24-well plate for cell viability and cAMP analysis. Cells are cultured in Dulbecco's Modified Eagle Medium with PHTPP (1 μM), or ethanol (0.1%) as the vehicle. The incubator is set to an atmosphere of 5% CO2 in air at 37°C, and cultures are allowed to acclimate for at least 24 h. The culture medium is then aspirated and replaced with serum-free DMEM/F12 containing 0.1 μM androstenedione. The cells are collected for intracellular cAMP and to test cell viability. They are for reference only. |
| In vitro | PHTPP acts as a selective antagonist for estrogen receptor beta (ERβ), significantly decreasing follicle-stimulating hormone (FSH)-mediated cyclic AMP (cAMP) production by 80% (p<0.01), without impacting basal cAMP levels. At a concentration of 10^-6 M, PHTPP inhibits estradiol (E2)-stimulated ERβ activity but does not affect E2-induced ERα activity. Furthermore, a high concentration of PHTPP (10^-6 M) marginally enhances class 1 Igf1 mRNA expression and promotes the DPN-induced increase in class 1 Igf1 mRNA expression. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 21.67 mg/mL (51.18 mM)
|
| Keywords | Inhibitor | inhibit | Estrogen Receptor/ERR | PHTPP |
| Inhibitors Related | Kaempferol | Tamoxifen | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Cholesterol | Melatonin | Chrysin | Allura Red AC | Natamycin | Ethisterone |
| Related Compound Libraries | Nuclear Receptor Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States