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Postion:Product Catalog >PhIP
PhIP
  • PhIP

PhIP NEW

Price $136 $338 $513
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PhIP CAS No.: 105650-23-5
Purity: 99.86% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePhIP
DescriptionPhIP is a heterocyclic aromatic amine (HAA) from cooked meat. It belongs to pyridine heterocyclic amine and is a 2B carcinogen with estrogen activity. PhIP forms adducts with DNA that promote cancer.
In vitroPhIP exerts extensive impacts through the activation of estrogen receptor alpha (ERα), leading to significant and overlapping alterations in miRNA expression. This deregulation of miRNA by PhIP may serve as a critical non-DNA-damaging carcinogenic pathway in breast cancer.
In vivoPhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents. PhIP causes inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe in hCYP1A-mice.[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 22.5 mg/mL (100.3 mM), Sonication and heating to 60℃ are recommended.
KeywordsPhIP
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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