PHGDH-IN-3 NEW
| Price | $98 | $239 | $355 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: PHGDH-IN-3 | CAS No.: 2893778-31-7 |
| Purity: 98.99% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | PHGDH-IN-3 |
| Description | PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research. |
| In vitro | PHGDH-IN-3 (compound D8) exhibits strong enzymatic inhibitory activity with an IC50 value of 2.8 μM and demonstrates high binding affinity for PHGDH protein with a Kd value of 2.33 μM. It is particularly effective against cell lines with amplified or overexpressed PHGDH genes and restricts de novo serine synthesis from glucose in MDA-MB-468 cells.[1] |
| In vivo | PHGDH-IN-3 (compound D8) (1, 3 mg/kg; p.o., i.v.) exhibits excellent in vivo pharmacokinetic properties.[1] Additionally, PHGDH-IN-3 (12.5, 25, 50 mg/kg; i.p.; once daily for 31 days) demonstrated significant antitumor effects in a PC9 xenograft mouse model.[1] |
| Storage | store at low temperature | Shipping with blue ice. |
| Solubility Information | DMSO : 90.0 mg/mL (181.6 mM), Sonication and heating to 70℃ are recommended. |
| Inhibitors Related | Disulfiram | Methotrexate | ALDH1A3-IN-3 | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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