The antipyretic analgesic effect of phenacetin is similar to that of acetyl salicylic acid. It is mainly used as antipyretic analgesic drug with slow and long-lasting effect. It has good efficacy in treating headache, neuralgia, arthralgia and fever, etc., but its anti-rheumatism and anti-inflammatory effect are weak. Excessive dose can lead to methemoglobin disease, resulting in hypoxia, long-term use can damage the kidney, and even cause nipple necrosis, should be used with caution. Due to its toxic side effects and the rapid development of other similar drugs, the drug has been stopped from being used alone, only as a raw material and other drugs combined with a compound preparation. It is often combined with aspirin and caffeine to form compound aspirin, which is composed of phenacetin 0.162 grams, aspirin 0.227 grams, caffeine 0.035 grams, less toxic, used to treat colds. If a small amount of pramine is added to the above drugs, it can also be made into Pramine cold tablets, which can be used to treat cold headache, neuralgia, rheumatic pain, etc. Phenacetin itself has no antipyretic and analgesic effect, in the body, after metabolic decomposition of acetaminophen, that is, paracetamol, to play the effect of Chemicalbook antipyretic and analgesic. Paraaminophenether was also decomposed. Paraaminophenether not only had no antipyretic and analgesic effect, but also was the main factor of the toxic and side effects of phenacetin. China began to produce phenacetin in 1954, from nitrochlorobenzene and ethanol etherification reaction to obtain p-nitrophenylether, and then reduced to amino phenylether and acetic acid acetylation reaction to produce. The mild analgesic effect of phenacetin can generally be maintained for 3-4 hours; The synergistic effect with salicylic acid enhances the analgesic effect. Clinically, it is mainly used for relieving heat and analgesia in small animals. This product is also one of the components of APC tablets. Internal process: easy to absorb, 20-30 minutes after taking the effect. Lasting 5-6 hours, after absorption, most of phenacetin rapidly deethylates to acetaminophen (paracetamol) in the liver, showing antipyretic and analgesic effects. Later, it is mainly eliminated from urine in the form of combination. A small portion is deacetylated to produce p-aminophenethers, which change hemoglobin to methemoglobin and thus exhibit the cyanosis toxicity of phenacetin.

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