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Postion:Product Catalog >PF-06726304
PF-06726304
  • PF-06726304

PF-06726304 NEW

Price $33 $46 $74
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PF-06726304 CAS No.: 1616287-82-1
Purity: 98.3% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePF-06726304
DescriptionPF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).
In vitroPF-06726304 suppresses the proliferation of Karpas-422 cells that harbor wild-type EZH2 (IC50: 25 nM). PF-06726304 suppresses H3K27me3 in Karpas-422 (IC50: 15 nM) [1].
In vivoIn a subcutaneous Karpas-422 xenograft model, PF-06726304 (200 and 300 mg/kg; BID for 20 days) suppresses tumor growth and causes robust modulation of downstream biomarkers[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 45 mg/mL (100.82 mM), Sonication is recommended.
Keywordsantitumor | H3K27me3 | Karpas-422 | PF 06726304 | EZH2 | Histone Methyltransferase | inhibit | Inhibitor | Y641N | PF-06726304 | PF06726304
Inhibitors RelatedBIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719
Related Compound LibrariesMethylation Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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