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Postion:Product Catalog >PF-06446846 hydrochloride
PF-06446846 hydrochloride
  • PF-06446846 hydrochloride

PF-06446846 hydrochloride NEW

Price $91 $226 $363
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PF-06446846 hydrochloride CAS No.: 1632250-50-0
Purity: 98.11% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePF-06446846 hydrochloride
DescriptionPF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
In vitroPF-06446846 suppresses the secretion of PCSK9 by Huh7 cells (IC50: 0.3 μM)[1].
In vivoPF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner. It also decreases total cholesterol levels[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 90.0 mg/mL (191.3 mM), Sonication is recommended.
DMSO : 225.0 mg/mL (478.4 mM), Sonication is recommended.
KeywordsPF-06446846 Hydrochloride | PF 06446846 Hydrochloride | PF06446846 hydrochloride | PF06446846 Hydrochloride | PF 06446846 hydrochloride

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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