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Postion:Product Catalog >PF-06260933
PF-06260933
  • PF-06260933

PF-06260933 NEW

Price $42 $58 $105
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PF-06260933 CAS No.: 1811510-56-1
Purity: 99.97% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePF-06260933
DescriptionPF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
In vitroTreatment with PF-06260933 significantly enhances the resistance of human aortic endothelial cells (EC) to TNF-α-induced increases in endothelial permeability in vitro.
In vivoTreatment with PF-06260933 does not modify plasma lipid content in a mouse model, yet it leads to decreased glucose levels, mirroring outcomes seen in whole-body-inducible Map4k4 knockout animals. Moreover, PF-06260933 administration results in either the attenuation of plaque progression or promotion of plaque regression in this model (46.0% versus 25.5%), alongside reductions in both plasma glucose and lipid content.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 50 mg/mL (168.49 mM)
KeywordsPF06260933 | inhibit | MAP4K | MAPK Kinase Kinase Kinase | PF-06260933 | PF 06260933 | Inhibitor
Inhibitors RelatedSodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | MAPK Inhibitor Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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