PF-05180999 NEW
| Price | $82 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: PF-05180999 | CAS No.: 1394033-54-5 |
| Purity: 99.43% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | PF-05180999 |
| 描述 | PF-05180999 (PF-999) is a selective and potent phosphodiesterase 2A (PDE2A) inhibitor that enhances long-term memory in a contextual fear conditioned reflex model in rats. |
| 體外活性 | PF-05180999 is a weak inducer of CYP3A4 with no direct inhibition of human recombinant cytochrome P450 enzymes (including 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A) and does not induce CYP1A2.PF-05180999 binds to PDE2A in rat, dog, and monkey with Ki values of 4.2 nM 8.4 nM, and 5.5 nM, with IC50 values of 2.6 nM, 5.2 nM, and 3.4 nM, respectively.For the other PDE isoforms, PF-05180999 was weakly active, with IC50s of 2.03 μM (PDE10A1), 26.969 μM (PDE7B), 50.09 μM (PDE11A4), and >56.25 μM (PDE1B1, PDE3A1, PDE4D3, PDE5A1, PDE6 (bovine), PDE8B, PDE9A1). [1] |
| 體內(nèi)活性 | PF-05180999 induced an acute, dose-dependent increase in cGMP levels in mouse cortex, striatum and hippocampus, but had no effect on cAMP levels and its downstream phosphorylated cAMP response element binding protein (p-CREB). In the radial arm maze (RAM) model of working memory, subcutaneous injection of 0.032-0.32 mg/kg PF-05180999 significantly reduced ketamine-induced working memory errors in rats. [1] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 40 mg/mL (96.53 mM), Sonication is recommended. |
| 關(guān)鍵字 | PF-05180999 | PF 05180999 |
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Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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