Perifosine NEW
| Price | $39 | $63 | $81 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Perifosine | CAS No.: 157716-52-4 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Perifosine |
| Description | Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity. |
| Cell Research | Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.(Only for Reference) |
| Kinase Assay | Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit. |
| In vitro | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| In vivo | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Insoluble H2O : 10 mM |
| Keywords | Protein kinase B | Inhibitor | Perifosine | NSC639966 | KRX 0401 | KRX0401 | inhibit | PKB | Apoptosis | D 21266 | NSC-639966 | D-21266 | Akt | Autophagy |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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