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Postion:Product Catalog >PCSK9-IN-11
PCSK9-IN-11
  • PCSK9-IN-11

PCSK9-IN-11 NEW

Price $47 $80 $163
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PCSK9-IN-11 Purity: 98.37%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NamePCSK9-IN-11
DescriptionPCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity, exhibiting inhibitory activity on PCSK9 transcription in HepG2 cells (IC50 = 5.7 μM) and capable of increasing LDL receptor (LDLR) protein levels. PCSK9-IN-11 is applicable for atherosclerosis research.
In vitroPCSK9-IN-11 (compound 5r) (0-25 μM, 24 h) significantly reduces PCSK9 protein levels and increases LDLR expression in a dose-dependent manner[1].
In vivoPCSK9-IN-11 (compound 5r) (0-1000 mg/kg, gavage, once) demonstrates superior safety in vivo, with an LD50 value exceeding 1000 mg/kg. Administered at 30 mg/kg via gavage once daily for 8 weeks, PCSK9-IN-11 significantly inhibits liver PCSK9 expression and slightly reduces serum PCSK9 levels [1].
StorageShipping with blue ice.
Solubility InformationDMSO : 3.82 mg/mL (10 mM)
KeywordsPCSK9IN11 | PCSK9-IN-11
Related Compound LibrariesBioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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