Ozagrel hydrochloride NEW
| Price | $44 | $71 | $107 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Ozagrel hydrochloride | CAS No.: 78712-43-3 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Ozagrel hydrochloride |
| 描述 | Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
| 體外活性 | Administration of 3 mg/kg Ozagrel significantly reduces the area and volume of cortical infarcts in rats following cerebral middle artery occlusion and reperfusion. Ozagrel also inhibits neural deficits in a rat model of microthrombosis and enhances deteriorated spontaneous motor activity and motor coordination in a conscious mouse model of cerebral ischemia-reperfusion. Furthermore, Ozagrel prevents the increase in lactate dehydrogenase activity in guinea pig pulmonary lavage fluid and blocks the production of thromboxane A(2) induced by oleic acid in guinea pigs, subsequently reducing the total protein concentration and the numbers of macrophages and neutrophils, as well as the expression of monocyte chemoattractant protein-1 and interleukin-8 mRNA in the entire lung. In cats, Ozagrel inhibits the reduction of brain tissue-specific gravity induced by reperfusion in the SHR model of cerebral ischemia-reperfusion and restores the decreased cortical PO(2) post-ischemia upon reperfusion. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostacyclin I(2) (PGI(2)), in the brain tissue following ischemia-reperfusion. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 65 mg/mL (245.55 mM) H2O : 48 mg/mL (181.3 mM) Ethanol : 6 mg/mL (22.66 mM) |
| 關(guān)鍵字 | OKY-046 | Inhibitor | TXA2 | antiplatelet | Ozagrel | aggregation | inhibit | Ozagrel Hydrochloride | Ozagrel hydrochloride | platelet | Prostaglandin Receptor | OKY046 | OKY 046 | thromboxane A2 |
| 相關(guān)產(chǎn)品 | Dabigatran Etexilate Mesylate | (S)-(+)-Ibuprofen | Pranoprofen | Tranilast | AEBSF hydrochloride | Heparin sodium salt | Rutin | Menadione | Ethamsylate | Rebamipide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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