OTSSP167 hydrochloride NEW
| Price | $34 | $48 | $80 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: OTSSP167 hydrochloride | CAS No.: 1431698-10-0 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | OTSSP167 hydrochloride |
| Description | OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM). |
| In vitro | OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 33 mg/mL (63 mM), Sonication is recommended. H2O : 7.14 mg/mL (13.63 mM), Sonication is recommended. |
| Keywords | OTSSP167 Hydrochloride | OTSSP-167 | OTSSP 167 | OTSSP167 | OTSSP-167 Hydrochloride | OTSSP167 hydrochloride | MELK | OTSSP-167 hydrochloride | Maternal embryonic leucine zipper kinase | inhibit | OTS167 | OTSSP 167 Hydrochloride | OTS-167 | OTS 167 | Inhibitor |
| Inhibitors Related | Antitumor agent-116 | HTH-01-091 | JTV-519 hemifumarate | MELK-8a Dihydrochloride | NMS-P715 | MELK-IN-1 | OTSSP167 | MELK-8a hydrochloride |
| Related Compound Libraries | Reprogramming Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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