Osimertinib dimesylate NEW
| Price | $30 | $39 | $55 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Osimertinib dimesylate | CAS No.: 2070014-82-1 |
| Supply Ability: 10g | Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Osimertinib dimesylate |
| 描述 | Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M). |
| 體外活性 | Osimertinib (AZD-9291) exhibits similar potency to early-generation tyrosine kinase inhibitors in inhibiting EGFR phosphorylation in EGFR cells with sensitizing EGFR mutations, including PC-9 (ex19del), H3255 (L858R), and H1650 (ex19del) (mean IC50s: 13-54 nM). Additionally, Osimertinib potently inhibits EGFR phosphorylation in T790M mutant cell lines H1975 (L858R/T790M) and PC-9VanR (ex19del/T790M), with mean IC50s below 15 nM [1]. |
| 體內(nèi)活性 | Tumor-bearing mice are treated with Osimertinib (5 mg/kg/day) for one to two weeks. Within days of treatment, 5 out of 5 C/L858R mice exhibit nearly 80% reduction in tumor volume by MRI, while 5 out of 5 vehicle-treated mice show tumor growth [1]. Comparable efficacy is observed at low doses (10 mg/kg per day) in three efficacy models, and excellent efficacy is also noted at 5 mg/kg per day [2]. |
| 存儲(chǔ)條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 0.4 mg/mL (0.58 mM), Sonication and heating are recommended. |
| 關(guān)鍵字 | Osimertinib Dimesylate | AZD 9291 | Osimertinib | Mereletinib | Osimertinib dimesylate | AZD9291 | AZD-9291 |
| 相關(guān)產(chǎn)品 | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Afatinib Dimaleate | Erlotinib hydrochloride | Erlotinib | Neratinib | Chalcone | Genistein | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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