天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Nervous system drugs>Antiparkinson Drugs>Orphenadrine
Orphenadrine
  • Orphenadrine

Orphenadrine NEW

Price $52 $68 $110
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-26

Product Details

Product Name: Orphenadrine CAS No.: 83-98-7
Purity: 99.38% Supply Ability: 10g
Release date: 2025/05/26

Product Introduction

Bioactivity

NameOrphenadrine
DescriptionOrphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.
In vitroOrphenadrine decreased CYP2B6 marker activity up to 45-57% in human liver microsomes and up to 80-97% in cell microsomes containing cDNA-expressed CYP2B6. Orphenadrine strongly decreased CYP2D6 marker activity by 80-90%. Orphenadrine also partially decreased the CYP1A2, CYP2A6, CYP3A4, and CYP2C19 marker activities.[4]
In vivoOrphenadrine (75 mg/kg/day; i.p.; for 3 days) was associated with a 2-fold induction of total hepatic P-450, a 5- and 2.4-fold induction of androstenedione 16 beta- and 6 beta-hydroxylase activity, respectively, and formation of an orphenadrine-P-450 MI complex. Western blots of orphenadrine-induced microsomes revealed a 20-fold increase in P-450 PB-B/D-immunoreactive protein.[2]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 50 mg/mL (185.61 mM), Sonication is recommended.
KeywordsSodiumChannel | Sodium Channel | Orphenadrine | NMDA receptor | muscarinic receptor | Cholinergic
Inhibitors RelatedAdiphenine hydrochloride | Phenytoin sodium | Procaine | Urethane | Ribavirin | Lidocaine | Valproic Acid | L-Aspartic aicd sodium | Lidocaine hydrochloride | D-Menthol | Choline chloride | Propoxur
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bitter Compound library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$46.00/100mg
VIP3Y
TargetMol Chemicals Inc.
2025-06-10
$0.00/25kg
VIP1Y
Shaanxi Dideu New Materials Co. Ltd
2025-04-10
$10.00/1Kg/Drum
VIP5Y
Hebei Chuanghai Biotechnology Co,.LTD
2021-07-16
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY