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Postion:Product Catalog >Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate
  • Orexin B, rat, mouse Acetate

Orexin B, rat, mouse Acetate NEW

Price $185 $452 $636
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Orexin B, rat, mouse Acetate Purity: 94.61%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameOrexin B, rat, mouse Acetate
DescriptionOrexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
In vitroOrexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].
In vivoHuman Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2].
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Insoluble
H2O : 2.5 mM
KeywordsOrexin B Acetate | Orexin B, rat, mouse Acetate | Orexin B
Inhibitors RelatedL-368,899 hydrochloride | YNT-185 | IPSU | MK-3697 | Filorexant | OXA (17-33) acetate | PF3274167 | ACT-462206 | Seltorexant | TCS 1102
Related Compound LibrariesPeptide Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

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Wuhan Senwayer Century Chemical Co.,Ltd
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
2024-10-23
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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