Product Details
| Product Name:
ONO-8130 |
CAS No.:
459841-96-4 |
| Purity:
97.82% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | ONO-8130 |
| Description | ONO-8130 is an orally available antagonist of EP1 receptor. |
| In vivo | Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5 mg/mL (10 mM)
|
| Keywords | Orally active | Inhibitor | inhibit | ONO-8130 | Bladder pain | Prostaglandin Receptor | Interstitial cystitis | PKR-like endoplasmic reticulum kinase | PERK | Hyperalgesia | Protein kinase R-like endoplasmic reticulum kinase | ONO8130 | ONO 8130 |
| Inhibitors Related | Angoroside C | Pranoprofen | Tranilast | Benorilate | Rutin | Ozagrel | Ethamsylate | Rebamipide | Evodiamine | Tebufelone | Timapiprant | p-Hydroxycinnamic acid |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
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$2800.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
|
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$997.00/50mg |
VIP3Y
|
TargetMol Chemicals Inc.
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2024-10-28 |
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$3.00/1KG |
|
Hong Kong Tiansheng New Material Trading Co., Ltd
|
2022-08-05 |
United States