Omeprazole (omeprazole) is a kind of proton pump inhibitor used for the treatment of peptic ulcer and gastroesophageal reflux disease (GERD) and other diseases. The active form of sulfonamide is then irreversibly combined with the sulfhydryl group of the proton pump through a disulfide bond to generate a complex of sulfenamide and proton pump (H+-K+-ATPase), thereby inhibiting the enzyme activity and making the intracellular H+ cannot be transported into the gastric cavity, blocking the final step of gastric acid secretion, which can greatly reduce the amount of gastric acid in the gastric juice. Therefore, this product has a strong and long-lasting inhibitory effect on gastric acid secretion caused by various reasons (such as basal gastric acid secretion and gastric acid secretion caused by histamine, pentagastrin and stimulation of the vagus nerve, including the inability of H2 receptor blockers. Inhibited gastric acid secretion by dibutyl cyclic adenylate). This has a certain relationship with the irreversibility of the inhibitory effect of this product on the proton pump, and the acid secretion can be restored only after the formation of a new proton pump.
use
1. For gastric and duodenal ulcers, stress ulcers, etc. 2. For reflux esophagitis, gastrinoma. 3. This product injection can also be used for: Digestive tract bleeding, such as peptic ulcer bleeding, anastomotic ulcer bleeding, etc., and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and upper gastrointestinal bleeding caused by gastric surgery. Acute gastric mucosal injury caused by stress or non-steroidal anti-inflammatory drugs. After general anesthesia or major surgery and comatose patients, to prevent acid reflux and aspiration pneumonia. 4. Combined with amoxicillin and clarithromycin, or combined with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp). The pharmacological effects, synthetic routes, uses, and precautions of omeprazole are organized by the Eastern editor of Chemicalbook. (2016-01-22)