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Postion:Product Catalog >API>Hormones and the Endocrine System>Others>Octreotide Acetate
Octreotide Acetate
  • Octreotide Acetate

Octreotide Acetate NEW

Price $30 $47 $70
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Octreotide Acetate CAS No.: 79517-01-4
Purity: 99.87% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameOctreotide Acetate
DescriptionOctreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
Animal ResearchOctreotide (acetate) is formulated in saline.MiceThirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq. RatTwelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at ?20°C until analysis.
In vivoGroups treated with Octreotide demonstrated a substantial reduction in tumor volume compared to those administered saline. The Octreotide-PPSG formulation (1.4 mg/kg, i.p.) exhibited a superior antitumor effect over the Octreotide-solution (100 μg/kg, i.p.). Furthermore, Octreotide treatments significantly suppressed the expression levels of SSTR2 and SSTR5 in rats with primary HCC, in comparison to the saline group, with Octreotide-PPSG achieving a more pronounced suppression than Octreotide-solution. In addition, a dose of octreotide acetate markedly lowered serum gastrin levels to about a third of the initial levels within 2 hours, maintaining this effect for around 6 hours. On the 21st day, a sustained-release form of octreotide acetate (5 mg intramuscular, every 4 weeks) was introduced.
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 29 mg/mL
Keywordsinhibit | Octreotide | SMS-201995 | SMS201995 | Inhibitor | SSTR | Somatostatin Receptor | SSTRs | Octreotide Acetate | SMS 201-995
Inhibitors Related2-Aminoethanethiol | FK962 | Cyclosomatostatin Acetate | L-803087 | Cortistatin 14, human, rat acetate | BIM-23190 aceate | L-796,778 | CYN 154806 TFA | (1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid | Somatostatin acetate
Related Compound LibrariesMacrocyclic Compound Library | Cyclic Peptide Library | JAK-STAT Compound Library | Peptide Compound Library | NO PAINS Compound Library | Preclinical Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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