Product Details
| Product Name:
OAC2 |
CAS No.:
6019-39-2 |
| Purity:
≥95% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | OAC2 |
| Description | OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1. |
| Cell Research | The Oct4-luc or Nanog-luc cells are treated with compound OAC1 or its structural analogs OAC2, OAC3 at 1 μM concentration or at indicated concentrations. Other compounds used include 2 μM BIO, 2 μM BIX, 2 μM 5'-azacytidine, 25 μg/mL Vitamin C, 10 nM Am580, 5 μM tranylcypromine, and 0.5 mM valporic acid. Luciferase reporter assays are performed 24 h after compound treatment or at indicated time points. For Topflash reporter assays, 0.2 μg β-catenin–responsive Topflash reporter gene plasmid is introduced into CV1 cells using trasfection. Compounds are added 6 h after transfection. Luciferase activity is measured 48 h after compound treatment using the Glo Luciferase Assay System[2]. |
| In vitro | Octamer-binding transcription factor 4 (Oct4) is crucial for initiating and maintaining cellular pluripotency, especially during early differentiation stages, and cannot be substituted by any family members for this function[1]. Essential for embryonic stem cell (ESC) pluripotency and reprogramming, Oct4, along with Sox2, Klf4, and c-Myc, benefits from the structural analog OAC2, which activates Oct4 and Nanog reporters like OAC1. OAC1 and its analogs OAC2 and OAC3 significantly enhance reprogramming efficiency by up to 2.75% and accelerate iPSC colony formation by 3 to 4 days[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 23.6 mg/mL (100 mM)
|
| Keywords | Slc22a3 | Oct3/4 | OAC2 | inhibit | POU5F1 | OAC 2 | OAC-2 | Inhibitor |
| Inhibitors Related | O4I1 | Oct3/4-inducer-1 | O4I2 | OAC1 | 3-O-Methylgallic acid | Retrorsine | Jatrorrhizine chloride |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2019-09-05 |
United States