NVP-BAG956 NEW
| Price | $745 | $1360 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-17 |
Product Details
| Product Name: NVP-BAG956 | CAS No.: 853910-02-8 |
| Purity: 99.80% | Supply Ability: 10g |
| Release date: 2025/06/17 |
Product Introduction
Bioactivity
| Name | NVP-BAG956 |
| Description | NVP-BAG956 (BAG956) is a potent PI3K/PDK inhibitor that inhibits PI3Kδ, PI3Kα, PI3Kγ, and PI3Kβ, shows strong cytotoxicity against T-ALL cell lines, and can be used to study melanoma. |
| Cell Research | One day after plating (7×10^3 cells/cm2), melanoma cells (A2058, B16F1, B16F10, C32, HBL, Malme, Malme3M, NA8, SKMel2, SKMel23, A375, Hs294T, WM35, and 1205lu cells) are exposed to LY294002 (25 μM), Wortmannin (500 nM), NVP-BAG956 (1 μM), NVP-BBD130 (1 μM), NVP-BEZ235 (1 μM), and ZSTK474 (1 μM), and Rapamycin (100 nM). Compound concentrations are set 2 log units above the IC50 in vitro to ensure full PI3K inhibition, except for the μM inhibitor LY294002. Cells are trypsinized and counted, and the volume is quantified using a Casy Counter and Analyser. To determine the nuclear volume, cells are resuspended in CASYton containing 0.5% Triton X-100, followed by repetitive pipetting (8×), before volume measurements. |
| In vitro | NVP-BAG956 inhibited PDK1 (IC50: 240 nM) and VEGFR1 (IC50: 2.56 μM). It also blocked the phosphorylation of PKB/Akt in A2058 cells with an IC50 of 67 nM.The inhibition of PKB/Akt phosphorylation was closely correlated with the reduction of A2058 cell proliferation, with an IC50 of 290 nM for NVP-BAG956.In the presence of NVP-BAG956, the A2058 cells were only able to exit from the G2-M phase, and thereafter stayed in the G1 phase. In addition, NVP-BAG956 significantly induced the expression of p27Kip1 in A2058 cells, but not in C32 cells. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (93.57 mM), Sonication is recommended. |
| Keywords | PI3Kδ | PI3Kγ | PI3Kβ | PI3Kα | PI3K | NVP-BAG-956 | NVP-BAG956 | NVP-BAG 956 | NVP BAG956 | BAG-956 |
| Inhibitors Related | Myricetin | Erucic acid | Sapanisertib | (2S,3R,4S)-4-Hydroxyisoleucine | 3-Methyladenine | Duvelisib (R enantiomer) hydrochloride | Isoprenaline hydrochloride | Quercetin | Inavolisib | Quercetin Dihydrate | Apilimod | Idelalisib |
| Related Compound Libraries | Bioactive Compound Library | Anti-Ovarian Cancer Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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