NV-5138 hydrochloride NEW
| Price | $862 | $1120 | $1610 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NV-5138 hydrochloride | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NV-5138 hydrochloride |
| Description | NV-5138 hydrochloride is a leucine analog and is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride can be used in the research of antidepressants [1] [2]. |
| In vivo | NV-5138 demonstrates nearly complete (100%) oral bioavailability and an elimination half-life of approximately 3 hours in plasma, observed after both intravenous and oral administration in male Sprague-Dawley rats weighing 250-400 g. At a dosage of 160 mg/kg, administered orally in a single dose, it significantly enhances the levels of phospho-mTOR and its downstream targets, phospho-p70S6K1 and phospho-4EB-P1, in synaptosomal preparations of the prefrontal cortex (PFC), indicating rapid biological activity [1][2]. Furthermore, chronic administration of NV-5138 (80 mg/kg, orally, daily for 7 days) has been found to exert antidepressant effects. Experimental dosages ranged from 40 to 160 mg/kg, with modes of administration including both single and daily doses for a period up to 7 days, underscoring its therapeutic potential [2]. Pharmacokinetic assessments were conducted at 1 mg/kg for intravenous and 5 mg/kg for oral dosages, establishing its pharmacokinetic profile [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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