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Postion:Product Catalog >NT157
NT157
  • NT157

NT157 NEW

Price $50 $129 $198
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: NT157 CAS No.: 1384426-12-3
Purity: 97.55% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNT157
DescriptionNT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
In vitroNT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro[2].
In vivoNT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 77 mg/mL (186.78 mM)
Ethanol : 25.83 mg/mL (186.78 mM)
KeywordsNT157 | NT-157 | NT 157
Inhibitors RelatedNifuroxazide | Balsalazide sodium hydrate | Fludarabine | Niclosamide | 2-(1,8-naphthyridin-2-yl)phenol | Ceritinib | CASIN | Diosgenin | Niclosamide olamine | Artesunate | Alantolactone | Stattic
Related Compound LibrariesAnti-Colorectal Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Prostate Cancer Compound Library | Immuno-Oncology Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

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2019-12-25
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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