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Postion:Product Catalog >NSC 617145
NSC 617145
  • NSC 617145

NSC 617145 NEW

Price $31 $44 $70
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-28

Product Details

Product Name: NSC 617145 CAS No.: 203115-63-3
Purity: 98.31% Supply Ability: 10g
Release date: 2025/05/28

Product Introduction

Bioactivity

NameNSC 617145
DescriptionNSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
In vitroNSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 6 mg/mL (15 mM), Sonication is recommended.
KeywordsWRN helicase | WRN | strand | RNASynthesis | RNA Synthesis | Rad51 | NSC 617145 | NHEJ | Inhibitor | inhibit | helicase | DSB | double | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | chromosomal | breaks | ATPase | abnormalities
Inhibitors Related5-Fluorouracil | Procaine | Rifaximin | Ribavirin | Guanidine hydrochloride | Methotrexate disodium | N-Nitrosodiethylamine | Cytarabine | Acyclovir | Thymidine | Temozolomide | Folic acid
Related Compound LibrariesDNA Damage & Repair Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Covalent Inhibitor Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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