NS-2028 NEW
| Price | $55 | $133 | $243 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: NS-2028 | CAS No.: 204326-43-2 |
| Purity: 99.44% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | NS-2028 |
| 描述 | NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1)-elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 μM). NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability. |
| 體外活性 | NS-2028 (10 μM; 30 mins) decreases VEGF-induced EC migration by inhibiting p38 MAPK activation. NS-2028 (10 μM; 24 hours) inhibits 25% cell number in comparation with those grown in the presence of a vehicle[2]. |
| 體內(nèi)活性 | In the avascular rabbit cornea, NS-2028 (p.o; 1 g/L; 8 days) displays an obvious reduction of new vessel formation in response to VEGF pellet implants[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 250 mg/mL (929.20 mM), Sonication is recommended. |
| 關(guān)鍵字 | inhibit | NS-2028 | Inhibitor | NS2028 | Guanylate Cyclase | NS 2028 |
| 相關(guān)產(chǎn)品 | LY83583 | Lificiguat | Sinitrodil | Riociguat | Nelociguat | Nitroprusside disodium dihydrate | Vericiguat | ODQ | Methylene Blue | Methylene Blue trihydrate | BAY 41-8543 | Cinaciguat |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 血管生成庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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