Noopept cas 157115-85-0

Use of Noopept

Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) . GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO, suggesting an antioxidant mechanism of action .in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions . The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) .Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity . Clinical trial: Discontinued

Company Introduction

Hebei Best Biological Technology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products,cosmetics, nutritional supplements and food additives areas.

Why Choose Us

1. Rich experience

We specialize in this filed for many years, our steriods and hormones exported to all over the world and established long friendly relations of cooperation with them.

2. Great quality,purity and favorable

Good quality is one of our biggest secret to success; you can get the best quality and service from us.

3. Safest and fastest delivery

We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass customs.

4. Good package

Unique ways to ship 10g to 100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.

5. Great after-sales service

Any needs or questions contact me freely.

FAQ

Q1: What is your MOQ?

A:Our MOQ is 10g, 100g and 1kg for your evaluation quality of our goods on the condition that sample charge is 100% paid.

Q2: Is there any discount?

A:Yes, for larger quantity, we always support with better price.

Q3: What payment terms do you accept ?

A:We'd like to accept T/T, L/C, Paypal, or Western Union.

Q4: How long will it take to get the goods?

A:Depending on your location, For small order, please expect 5-7 days by DHL, UPS, TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q5: How do you treat quality complaint?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6: How can we trust you?

A: You are always warmly welcomed to visit us at any time. Before we start B2B, MIC has audited our company on-spot and approved our credit.

Q7: Do you test all your goods before delivery?

A: Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

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