NMS-P715 NEW
Price | $72 | $98 | $155 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: NMS-P715 | CAS No.: 1202055-32-0 |
Purity: 98.41% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | NMS-P715 |
Description | NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). |
In vitro | NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1]. |
In vivo | NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 2 mg/mL (2.96 mM), Sonication is recommended. |
Keywords | NMS-P 715 | Monopolar spindle 1 | Mps1 | NMS P715 | NMS-P-715 | inhibit | NMSP715 | Inhibitor | NMS-P715 |
Inhibitors Related | Sodium lauryl sulfoacetate | TBCA | Vemurafenib | Ellagic acid | CMPD1 | SKLB-163 | Emodin | sodium lauroyl-α-hydroxyethyl sulfonate | LY-364947 | Takinib | NG25 | LY294002 |
Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Osteogenesis Compound Library | PI3K-AKT-mTOR Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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