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Postion:Product Catalog >Nicotredole
Nicotredole
  • Nicotredole

Nicotredole NEW

Price $38 $59 $97
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Nicotredole CAS No.: 29876-14-0
Purity: 99.67% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNicotredole
DescriptionNicotredole (Tryptamide) (Tryptamide) is an orally active analgesic and anti-inflammatory agent. Nicotredole exhibits evident anti-inflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.
In vitroNicotredole inhibits prostaglandin synthetase activity in an in vitro assay [1].
In vivoNicotredole exhibits anti-inflammatory properties as evidenced by its effectiveness in reducing carrageenin-induced paw edema in rats. Additionally, it has been shown to counteract pyrogen-induced hyperthermia, offer analgesic benefits, extend hexobarbital-induced sleep duration, and suppress locomotor activities in both rats and mice. Intraperitoneally (i.p.), Nicotredole holds lethal doses (LD50) of 1260 mg/kg for male rats and 1980 mg/kg for male mice, whereas orally (p.o.), its LD50 values are 8.5 g/kg for male rats and 9.3 g/kg for male mice. Administered either orally or intraperitoneally at a dose of 25 mg/kg, Nicotredole is rapidly absorbed and eliminated, with half-lives ranging from 4.92 to 17.5 minutes for absorption and 55.72 to 74.52 minutes for elimination. It achieves maximum concentration (C max) levels of 11-13 μg/cm^3 within 30 minutes, resulting in area under the curve (AUC) values between 21.40 and 27.30 μg?h/cm^3.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 25 mg/mL (94.23 mM), Sonication is recommended.
Keywordsanti-inflammatory | analgesic | ulcerogenic | inhibit | Nicotredole | Inhibitor
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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