Nicardipine hydrochloride NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Nicardipine hydrochloride | CAS No.: 54527-84-3 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Nicardipine hydrochloride |
| Description | Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator. |
| In vitro | Nicardipine significantly reduced systolic blood pressure in spontaneously hypertensive rats. In spontaneously hypertensive rats, Nicardipine significantly decreased the intima-media thickness and increased the lumen area at the level of cerebral arteries and small molluscum arteriosum.Nicardipine increased the number of neurons in the occipital cortex and frontal cortex in the SHR and inhibited the proliferation and hypertrophy of GFAP-positive astrocytes.Nicardipine also increased the number of neurons in the CA1 area of the hippocampus. increase in the number of neurons in the CA1 region of the hippocampus and reduced the size and number of astrocytes in gray and white matter. Nicardipine (5 mg/kg) in combination with flunarizine (80 mg/kg) and nimodipine (80 mg/kg) significantly potentiated the protective effect of ethosuximide (50 mg/kg) or valproic acid (100 mg/kg) against clonic seizures in mice. Nicardipine (40 mg/kg, 2 times/day for 8 weeks) reduced plaque area by 49.2% in rabbits (cholesterol-fed).Nicardipine (40 mg/kg) reduced aortic cholesterol accumulation in cholesterol-fed rabbits by 74.5%.Nicardipine (100 mg/kg) caused a significant transient reduction in cat Nicardipine (100 mg/kg) caused a significant transient reduction in retinal blood flow in cats. Although Nicardipine (100 mg/kg) decreased mean arterial blood pressure in cats, it significantly increased blood flow to the ONH, suggesting that Nicardipine benefits optic nerve hypoplasia tissue. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (87.21 mM) |
| Keywords | Ca channels | Nicardipine hydrochloride | Nicardipine | Autophagy | Calcium Channel | Ca2+ channels | RS 69216 | blocker | inhibit | blood | YC93 | Inhibitor | RS69216 | Nicardipine Hydrochloride | pressure | angina | YC-93 | YC 93 | cardiac | YC 93 Hydrochloride | YC93 Hydrochloride |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | GPCR Compound Library | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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