NF-κΒ activator 2 NEW
| Price | $95 | $138 | $238 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NF-κΒ activator 2 | CAS No.: 2375281-44-8 |
| Purity: 99.32% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NF-κΒ activator 2 |
| Description | NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1]. |
| In vitro | NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-?Bs. |
| In vivo | NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice [1]. Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (838.17 mM), Sonication is recommended. |
| Keywords | SOD2 | sclerosis | Nuclear factor-κB | Nuclear factor-kappaB | NF-κΒ activator 2 | NFκΒ activator 2 | NF-κB | NF-kb activator 2 | NF-kappabeta activator 2 | NF-?B | NF κΒ activator 2 | lateral | Inhibitor | inhibit | amyotrophic | ALS |
| Inhibitors Related | Sodium Houttuyfonate | Zingerone | Lidocaine | α-Lipoic Acid | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Antioxidant Compound Library | Pyroptosis Compound Library | Neuroprotective Compound Library | Anti-Prostate Cancer Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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