Neratinib (HKI-272) NEW
Price | Get Latest Price |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1KG |
Update Time: | 2024-11-19 |
Product Details
Product Name: Neratinib (HKI-272) | CAS No.: 698387-09-6 |
Min. Order: 1g | Purity: 98% HPLC |
Supply Ability: 1KG | Release date: 2024/11/19 |
Neratinib effect
Neratinib is a kinase inhibitor that binds irreversibly to epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and HER4. In vitro, neratinib decreased EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in EGFR and/or HER2 expressing cancer cell lines. Neratinib human metabolites M3, M6, M7 and M11 inhibit the activity of EGFR, HER2 and HER4 in vitro. In vivo, oral administration of neratinib inhibited tumor growth in mouse xenograft models with tumor cell lines expressing HER2 and EGFR.
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- Since: 2014-09-09
- Address: No.28 Hua Long Road,Ji Nan City,China
+86-13153181156
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